Detection of a hypersialylated β1 integrin endogenously expressed in the human astrocytoma cell line A172
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چکیده
منابع مشابه
Study of Anti Cancer Property of Scrophularia striata Extract on the Human Astrocytoma Cell Line (1321)
There are considerable efforts to identify naturally occurring substances as new drugs in cancer therapy. Many components of medicinal plants have been identified that possess substantial anticancerous properties. This prompted us to investigate the effect of Scrophularia striata (an Iranian species belonging to the Scrophulariace family) extract on the growth of astrocyte cancer cell line (132...
متن کاملStudy of Anti Cancer Property of Scrophularia striata Extract on the Human Astrocytoma Cell Line (1321)
There are considerable efforts to identify naturally occurring substances as new drugs in cancer therapy. Many components of medicinal plants have been identified that possess substantial anticancerous properties. This prompted us to investigate the effect of Scrophularia striata (an Iranian species belonging to the Scrophulariace family) extract on the growth of astrocyte cancer cell line (132...
متن کاملIdentification of Novel Hypoxia Response Genes in Human Glioma Cell Line A172
Objective(s): Hypoxia is a serious challenge for treatment of solid tumors. This condition has been manifested to exert significant therapeutic effects on glioblastoma multiform or (WHO) astrocytoma grade IV. Hypoxia contributes numerous changes in cellular mechanisms such as angiogenesis, metastasis and apoptosis evasion. Furthermore, in molecular level, hypoxia can cause induction of DNA br...
متن کاملHeat-induced apoptosis in human glioblastoma cell line A172.
OBJECTIVE Hyperthermia has been clinically applied to some types of brain tumors. However, the detailed mechanisms of this growth inhibition are not clear. The effect of mild hyperthermia on cultured human glioblastoma cell line, A172, was studied. METHODS A172 cells were heat treated (43-44.5 degrees C) for 1 hour in the growing phase. Cell viability was assessed by trypan blue dye exclusion...
متن کاملin vitro analysis of csa-induced hepatotoxicity in hepg2 cell line: oxidative stress and α2 and β1 integrin subunits expression
background cyclosporine a (csa)-induced hepatotoxicity could be due to a reduction in α2β1 integrin expression that may either be from the direct effect of csa itself or from reactive oxygen species (ros) overproduction. objectives in this study we aimed to identify the cellular mechanisms underlying csa-induced hepatic injury by investigating the activation patterns of the antioxidant enzymes,...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2008
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.32.5.1021